When flying in the Standard Pressure Region, what should the altimeter be set to?

When flying in the Standard Pressure Region, the altimeter should be set to 29.92 inches of mercury. This setting is crucial because it provides a standard reference point for altimeter indications, ensuring that pilots can accurately determine their aircraft's altitude relative to sea level. The Standard Pressure Region is defined as the area where the atmospheric pressure is close to this standard, typically above the transition altitude. By using 29.92 inches of mercury, pilots can effectively communicate and maintain altitude across different aircraft, ensuring safety and consistency in navigation and air traffic control.